Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways
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چکیده
منابع مشابه
The early allergic response in small airways of human precision-cut lung slices.
To study the role of small airways in the early allergic response (EAR), the method of human precision-cut lung slices (PCLS) was developed and used to examine the bronchoconstriction elicited by passive sensitisation and allergen provocation. Viable human PCLS of 250-microm thickness containing airways <1.5 mm in outer diameter were prepared from lung lobes obtained from lung resection and tak...
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Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a 1 mouse model of chronic allergic airways disease 2 3 1, Chantal Donovan, Simon R Bailey, Jenny Tran, Gertruud Haitsma, Zaridatul A 4 Ibrahim, Simon R Foster, Mimi L K Tang, 1,2,4+ Simon G Royce, Jane E Bourke 5 6 Biomedicine Discovery Institute and Department of Pharmacology, Monash University, 7 Clayton,...
متن کاملMaterial model of lung parenchyma based on living precision-cut lung slice testing.
We describe a novel constitutive model of lung parenchyma, which can be used for continuum mechanics based predictive simulations. To develop this model, we experimentally determined the nonlinear material behavior of rat lung parenchyma. This was achieved via uni-axial tension tests on living precision-cut rat lung slices. The resulting force-displacement curves were then used as inputs for an...
متن کاملCorrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice
[This corrects the article on p. 309 in vol. 7, PMID: 27559314.].
متن کاملVideomicroscopy of methacholine-induced contraction of individual airways in precision-cut lung slices.
Contraction of airways of different size can be studied in viable lung slices by videomicroscopy. However, at present, application of this technique is limited by the heterogeneous responses obtained. We investigated the use of precision-cut lung slices to examine contraction of individual airways. Lung slices of 250 +/- 20 microns were prepared from Wistar rats and cultured in a roller incubat...
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ژورنال
عنوان ژورنال: Xenobiotica
سال: 2019
ISSN: 0049-8254,1366-5928
DOI: 10.1080/00498254.2018.1536814